J. Pines, T. Hunter, "Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2," Cell, 58, 833-46, 8 September 1989.
Jonathon Pines (The Salk Institute, La Jolla, Calif.): "The control of mitosis has recently been one of the most active areas of cell cycle research. One of the critical components in the control of mitosis is the cyclin family of proteins. Cyclins are found associated with the serine/threonine protein kinase, p34cdc2, as components of the mitosis-specific histone H1 kinase and M-phase Promoting Factor (MPF). Cyclins, which were first found in cleaving embryos, such as clams, sea urchins, and frogs, are characterized by their constant synthesis during interphase and specific destruction at mitosis. Our paper was the first to show that cyclins are found in mammalian cells and that their behavior is conserved from the embryonic to the somatic ...
