Edited by: Thomas W. Durso
S. Matsuoka, M.C. Edwards, C. Bai, S. Parker, P. Zhang, A. Baldini, J.W. Harper, S.J. Elledge, "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene," Genes & Development, 9:650-62, 1995. (Cited in 130 papers as of April 1997)
Comments by Stephen J. Elledge, department of biochemistry, Baylor College of Medicine, and Howard Hughes Medical Institute
Cyclin-dependent kinases (Cdks) are a group of molecules that help to control cellular duplication. According to Stephen J. Elledge, a professor of biochemistry at Baylor College of Medicine and a Howard Hughes Medical Institute investigator, Cdks often receive the information that determines whether a cell will copy itself. "By regulating them, you control cell proliferation," he explains.
SEEKING CKIs: Baylor’s Stephen Elledge helped find a protein that plays a role in Wilms' tumor and Beckwith-Wiedemann syndrome. Molecules called Cdk inhibitors (CKIs) bind ...
