Contributors

Keith D. Wilkinson (far left) began studying the ubiquitin pathway in 1979 because it was “brand new.” He was recruited to Nobel Prize–winner Irwin Rose’s lab at the Fox Chase Cancer Center just a few short years after ubiquitin was first discovered. Today, Wilkinson is still figuring out the mysteries of a protein that is found in all eukaryotic cells and is fundamental to the cell cycle. He is currently identifying a host of enzymes that regulate ubiquitin-dependent processes, with the expectation that the enzymes will be good drug targets in disease. Wilkinson first met his coauthor David Fushman at a biannual ubiquitin meeting, where “everybody who is anybody in this field got their start.” Chains of ubiquitin are only distinguished by their pattern of connections, and Fushman wants to understand how the connections affect the signaling process. In their feature article, "On the Chain Gang," you can read about ...