HIV (green) buds out of a cell.CDC, C. GOLDSMITHViruses that infect heat-loving archaebacteria and viruses that infect humans have more in common than previously thought. A virus that infects the hot spring archaebacterium Sulfolobus solfataricus has been found to recruit the same set of host proteins that human pathogens, such as HIV and Ebola, do when it is time to emerge from infected cells.
“The new work yields insight into the evolution of the relationship between hosts and viruses and, more importantly, presents us with a new and simple model system to study how viruses can hijack and utilize cellular machineries," Indiana University biochemist Stephen D. Bell said in a press release.
The hot spring virus, found in Yellowstone National Park and called Sulfolobus turreted icosahedral virus (STIV), and the eukaryotic viruses all recruit a set of host proteins called the Endosomal Sorting Complexes Required for Transport (ESCRT). ESCRT aids in cell division in both eukaryotes and archaebacteria, as well as playing other roles.
Both types of viruses hijack ESCRT to help them assemble themselves within the host cytoplasm and then to prepare to bud out of the cell ...
