For Genes Author: Holly Ahern

For a geneticist, pinpointing a mutation in a human gene that might be responsible for an inherited disease can be likened to the proverbial search for a needle in a haystack. While mo-lecular biologists sift through the 3 billion base pairs in the human genome in search of disease-causing genes, other scientists choose to approach the problem from the perspective of the mouse, a model system for mammal research.

Because mice and humans are members of the same group of animals and develop similar diseases, mapping mouse mutations that appear to be linked to a genetic disease is considered by many scientists a springboard from which disease-causing genes in humans might also be mapped.

Amplicor AMPLICOR LINE: Roche's kits have probes that bind to specific target sequences in pathogenic organisms. Whether experiments are performed with the human genome or with the mouse genome, locating a...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?