Escape from Mitochondria

For this article, Steve Bunk interviewed John C. Reed, scientific director, The Burnham Institute, La Jolla, Calif. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. J.M. Jürgensmeier, Z. Xie, Q. Deveraux, L. Ellerby, D. Bredesen, J.C. Reed, "Bax directly induces release of cytochrome c from isolated mitochondria," Proceedings of the National Academy of Sciences, 95:4997-5002, April 1998. (Cited in more than 185 papers since publication) In a typical day, 60 or 70 billion cells perish in your body," notes John C. Reed, scientific director of the Burnham Institute in La Jolla, Calif. Much of this normal cellular turnover involves apoptosis. When apoptotic pathways are defective, insufficient cell death can lead to cancers and autoimmune diseases, and excessive cell death can result in neurodegeneration, stroke, or AIDS. Accordingly, much ...