faculty of 1000
Volume 16 | Issue 13 | 28 | Jun. 24, 2002

Form and Function Finally Prove Mitchell's Proton Motive Force

Perseverance, perspiration and a creative bent pay off | By Susan Jenkins

The Faculty of 1000 is a
Web-based literature awareness tool published by BioMed Central. For more information visit www.facultyof1000.com.

In 1961, Nobel laureate Peter Mitchell's provocative pairing of chemistry and biology gave birth to his chemiosmotic hypothesis and its corollary proton motive force, or what Mitchell liked to call proticity.1 Forty years later, the authors of these two selected Faculty of 1000 papers2,3 have provided structural and functional confirmation of Mitchell's theories.

In the first paper, So Iwata and his graduate student Mika Jormakka provide molecular proof of proton motive force and an energy conserving redox loop,2 another Mitchell proposal. In the second manuscript, Andreas Matouschek and colleague Shihai...

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