Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

M. Lachner et al., "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins," Nature, 410:116-20, 2001. (Cited in 202 papers)

A.J. Bannister et al., "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain," Nature, 410:120-4, 2001. (Cited in 224 papers)

Beyond A, C, T, and G lies an epigenetic level of heritable control that has reached the forefront of biomedical research. Histone modification patterns, like multicolored highlighting in the genome's book of life, tell eukaryotic cells when to turn genes on and off, thus making sense of its DNA instructions. In 1993, researchers first pondered whether these alterations on N-terminal tails...

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