The paper:
R. Basto et al., “Centrosome amplification can initiate tumorigenesis in flies,” Cell, 133:1032–42, 2008. (Cited in 32 papers)
The finding:
Tumor cells display both chromosomal instability and centrosome amplification, in which they have extra copies of the organelles that orchestrate the movement of microtubules and the progression through the cell cycle. But last year, a group led by researchers at the Gurdon Institute in the United Kingdom found that centrosome amplification alone is enough to incite tumor growth.
The missing step:
Cell biologist Jordan Raff and his colleagues developed a line of Drosophila that had extra centrosomes in 60% of their cells but largely normal chromosomes. “It was a big deal that they separated centrosome amplification from chromosome abnormalities,” says William Saunders, a University of Pittsburgh cell biologist who was not involved with the study.
The unexpected:
“The first big surprise was that centrosome amplification did not create ...
