Edited by: Steven Benowitz
R.A. Shimkets, D.G. Warnock, C.M. Bositis, C. Nelson-Williams, J.H. Hansson, M. Schambelan, J.R. Gill, S. Ulick, R.V. Milora, J.W. Findling, C.M. Canessa, B.C. Rossier, R.P. Lifton, "Liddle's syndrome: Heritable human hypertension caused by mutations of the beta subunit of the epithelial sodium channel," Cell, 79:407-14, 1994. (Cited in more than 70 papers as of October 1996)

Comments by Richard A. Shimkets, Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine.

Richard Shimkets
LOOKING AHEAD: Yale's Richard Shimkets questions how genetic mutations caused hypertension.
Hypertension contributes to as many as 200,000 deaths a year from stroke, heart attack, and kidney disease. Liddle's syndrome is a rare but severe form of inherited hypertension. In this paper, an international team of researchers led by Richard Lifton of Yale University School of Medicine report finding a gene that, when mutated, is responsible for Liddle's syndrome....

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