Edited by: Steven Benowitz
R.A. Shimkets, D.G. Warnock, C.M. Bositis, C. Nelson-Williams, J.H. Hansson, M. Schambelan, J.R. Gill, S. Ulick, R.V. Milora, J.W. Findling, C.M. Canessa, B.C. Rossier, R.P. Lifton, "Liddle's syndrome: Heritable human hypertension caused by mutations of the beta subunit of the epithelial sodium channel," Cell, 79:407-14, 1994. (Cited in more than 70 papers as of October 1996)
Comments by Richard A. Shimkets, Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine.
LOOKING AHEAD: Yale's Richard Shimkets questions how genetic mutations caused hypertension. Hypertension contributes to as many as 200,000 deaths a year from stroke, heart attack, and kidney disease. Liddle's syndrome is a rare but severe form of inherited hypertension. In this paper, an international team of researchers led by Richard Lifton of Yale University School of Medicine report finding a gene that, when mutated, is responsible for Liddle's syndrome. The mutated gene ...
