Hypothetical Concerns

I was greatly heartened by David Horrobin's article "Discouraging Hypotheses Slows Progress" [The Scientist, Nov. 26, 1990, page 13]. For 10 years I have been attempting to publish what amounts to a unified hypothesis of the evolutionary development of intermediary metabolic cell growth control and, in particular, how it relates to cellular differentiation and cancer cell growth. Of course, a full testing of the hypothesis would be nothing short of a Manhattan Project-sized undertaking. However

Written byGregory Bambeck
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Although I graduated at the top of my class, and in the top 1 percent worldwide, this inability to publish a unifying theory has not only had detrimental consequences on my career, but also casts serious aspersions upon both the recognized scientific leadership and the hierarchical bureaucratic publication mechanism in the medical, biomolecular, and allied sciences. It is nothing short of ethical scientific crime when United States patents can be granted, based upon a theory that can't even be published. How much "proof in the pudding" is required to couple theory and application to publication?

I find Horrobin's efforts to be laudable and downright heroic. We theoreticians tire of receiving blanket rejections by publication staff members who do not even permit our work to be submitted to the review process. There is nothing more demeaning to a qualified professional than to be rejected from peer review consideration by the publication ...

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