Hypothetical Concerns

I was greatly heartened by David Horrobin's article "Discouraging Hypotheses Slows Progress" [The Scientist, Nov. 26, 1990, page 13]. For 10 years I have been attempting to publish what amounts to a unified hypothesis of the evolutionary development of intermediary metabolic cell growth control and, in particular, how it relates to cellular differentiation and cancer cell growth. Of course, a full testing of the hypothesis would be nothing short of a Manhattan Project-sized undertaking. However

Written byGregory Bambeck
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Although I graduated at the top of my class, and in the top 1 percent worldwide, this inability to publish a unifying theory has not only had detrimental consequences on my career, but also casts serious aspersions upon both the recognized scientific leadership and the hierarchical bureaucratic publication mechanism in the medical, biomolecular, and allied sciences. It is nothing short of ethical scientific crime when United States patents can be granted, based upon a theory that can't even be published. How much "proof in the pudding" is required to couple theory and application to publication?

I find Horrobin's efforts to be laudable and downright heroic. We theoreticians tire of receiving blanket rejections by publication staff members who do not even permit our work to be submitted to the review process. There is nothing more demeaning to a qualified professional than to be rejected from peer review consideration by the publication ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH