Improving T Cell Tumor-Specificity Using Single Cell Co-culture
Webinar

Improving T Cell Tumor-Specificity Using Single Cell Co-culture

In this webinar, Edward Han, Jospeh Zenga, and Tyce Kearl will discuss how optofluidic technologies unlock key immuno-oncology insights for translational applications.

Share

This webinar will be hosted live and available on-demand

Wednesday, October 2nd, 2024
11:00 AM - 12:30 PM ET 

Certain cancer types remain treatment-resistant with limited response to immunotherapy. Researchers investigate the functionality and tumor-specificity of immune cells, including tumor-infiltrating lymphocytes (TILs), to uncover the immunotherapy resistance mechanisms in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Using single-cell proteomics and optofluidic technology to establish an autologous single tumor cell-single T cell co-culture platform, scientists at the Medical College of Wisconsin have identified and visualized individual tumor-killing TILs in real time, demonstrating that cancer-specific T cells exist across HNSCC patients with rescuable immunogenicity. 

In this webinar brought to you by Bruker Cellular Analysis, Edward Han will introduce the optofluidic technology used for single cell co-culture, and Joseph Zenga and Tyce Kearl will discuss how their findings lay the foundation for development of tumor-specific T cell immunotherapies in HNSCC.

Topics to be covered

  • Measuring tumor-specific TIL functionality and tumor-killing capacity in HNSCC through immunophenotyping and single-cell proteomics
  • Establishing a single-cell co-culture system to identify and visualize cancer cell-T cell interactions in real-time 
  • How the Beacon optofluidic platform provides researchers with the ability to achieve live single-cell analysis and single-cell functional characterization
Joseph Zenga, MD
Joseph Zenga, MD
Associate Professor
Division Chief
Department of Otolaryngology and Communication Sciences
Medical College of Wisconsin
Tyce Kearl, PhD
Tyce Kearl, MD, PhD
Assistant Professor
Department of Medicine 
Hematology and Oncology
Medical College of Wisconsin
Edward Han, PhD

Edward Han, PhD
Product Manager 
Bruker Cellular Analysis

Sponsored by

  • Bruker Logo

Top Image Credit:

3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide