By controlling how many ribosomes coat a certain mRNA in C. elegans, intracellular insulin signaling can regulate how many copies of a protein are made, and how quickly, giving cells more flexibility when responding to changes in the environment.
C. elegans
Image: Wikimedia commons,
Bob Goldstein, UNC Chapel Hill
The results, published, in the September 8th issue of Cell Metabolism, hold implications for a range of fields, including aging and diabetes, in which insulin signaling is known to play a role. "We have found a new way in which insulin controls the proteins that are made, and some of those proteins are really important for the survival of the worms," said lead author linkurl:Gordon Lithgow,; of the Buck Institute for Age Research. "That throws up questions as to whether insulin is doing the same in humans and that presents a whole new set of targets for potential therapies...
C. elegansG. McColl, et al., "Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans," Cell Metabolism, 12: 260-72, 2010.

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