The importance of integrin proteins is evident from the fact that scientists studying these proteins represent a range of fields within the life sciences as diverse as the functions of the integrins themselves. For example, insights regarding integrins have been contributed by researchers interested in topics such as embryonic development, blood clotting, wound healing, and immune surveillance.1 Some researchers were introduced to integrins because of an interest in diseases associated with integrin hypo- or hyperactivity. Others are focused on fundamental cellular processes such as growth, differentiation, motility, or regulation of cell shape. With the implication of integrins in so many diverse areas of research, the field is booming: Medline cited more than 3,000 articles relevant to members of the integrin family of proteins last year, and integrin research still appears to be going full-steam ahead, as more than 2,000 additional articles have already been published during the first half of ...
Integral Connections
Click to view the PDF file: Suppliers of Integrin-Related Reagents Courtesy of Rick HorwitzReprinted with permission from the Journal of Cell BiologyPaxillin-GFP in WI38 human fibroblast cells showing paxillin turnover as cells migrate. The image is an overlay of 2 separate time points. Editor's note: A group of scientists led by M. Amin Arnaout at Massachusetts General Hospital published the first crystal structure of the human integrin aVb3 extracellular domain, on September 9, 2001.(www.sc
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Deborah Fitzgerald
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