Is It a Code: The Debate

FEATUREEpigenetics Is It a Code: The Debate Yes: An epigenetic histone code may allow for unprecedented predictive power BY BRYAN M. TURNERARTICLE EXTRASRelated Articles: The Nucleosome UntangledHistones serve as slates to a dizzying array of modifications, but researchers are confident they can decipher the epigenetic puzzle.The nuclear signaling networks that operate through chromatin de

Written byBryan M. Turner and Steven Henikoff
| 6 min read

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

Yes: An epigenetic histone code may allow for unprecedented predictive power

The short answer is that a code takes us into a new dimension by addressing the possibility that environmental effects may be inherited from one cell generation to the next and possibly through the germ line. A histone-based epigenetic code would act in parallel with the genetic code and should offer comparable predictive power. The search for such a code is surely worth undertaking, but first we must establish what we are looking for, and where to look.

As a start, we might borrow from semiotics. As 40 million plus readers of a recent best seller are likely aware, semiotics is the study of signs and symbols and their use or meaning. A semiotic system consists of a sign, its meaning (i.e., the outcome), and the code by which the sign brings that meaning into effect. In practice, one ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio 
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

cytiva logo
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

cytiva logo

Products

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

brandtechscientific-logo

BRANDTECH Scientific Launches New Website for VACUU·LAN® Lab Vacuum Systems