William F. Loomis
Department of Biology University of California, San Diego
La Jolla, Calif.
" A mutation found in 1913 to affect the eyes of Drosophila has been shown to be an insertion of a transposable element into an intron of the rough gene. The product of this gene carries a homeodomain and appears to regulate genes in two cells in each ommatidium that are necessary for proper differentiation of adjacent cells.
A. Tomlinson, B.E. Kimmel, G.M. Rubin, "rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye," Cell, 55 (5), 771-84, 2 December 1988.
" Naked Vg1 mRNA is drawn to the vegetal pole where it is tightly bound to the cortex during the final stages of differentiation of frog oocytes into eggs. This mRNA codes for a TGFb-like protein that may direct cell fate following fertilization.
J. Yisraeli, D. Melton, ...
