J. Chun et al., "GPR92 as a new G(12/13)- and G(q)-coupled lysophosphatidic acid receptor that increases cAMP, LPA(5)," J Biol Chem, 281:23589-97, 2006. (Cited in 75 papers)
Between 1996 and 2006, researchers identified four G protein-coupled receptors (GPCRs) as lysophosphatidic acid (LPA) receptors, LPA1-4. Jerold Chun's team at The Scripps Research Institute screened collections of orphan GPCRs, using reverse transfection to measure LPA-dependent cellular morphological changes, and identified a potential LPA receptor. Through heterologous expression and measuring downstream signaling, Chun identified GPR92 as a new receptor, LPA5.
Sequencing revealed that LPA5 shared homology with LPA4, but not the other three, suggesting there were at least two distinct families of LPA receptors. "People are now looking more seriously at the possibility of other non-homologous [LPA] receptors, mediating a variety of physiological and pathophysiological actions," says Chun, suggesting the two subfamilies mediate different cellular responses.
Since publication, researchers have reconfirmed LPA4-5 to ...
