Mail

Junk in our genome? Re: "Junk worth keeping,"1 just because functions have been identified for some regions of genomes thought to be non-functional does not mean that all regions thought to be junk are functional. This is particularly true for bloated genomes (like the human genome) which are loaded with parasitic elements. A nearly neutral model for the evolution of eukaryotic genome structure, proposed by Michael Lynch2, suggests that mutational biases can overwhelm the cos


Register for free to listen to this article
Listen with Speechify
0:00
5:00
Share

Re: "Junk worth keeping,"1 just because functions have been identified for some regions of genomes thought to be non-functional does not mean that all regions thought to be junk are functional. This is particularly true for bloated genomes (like the human genome) which are loaded with parasitic elements.

A nearly neutral model for the evolution of eukaryotic genome structure, proposed by Michael Lynch2, suggests that mutational biases can overwhelm the costs associated with many deleterious changes if population sizes are small enough. If so, many features of eukaryotic genomes (introns, elaborate transcriptional regulatory systems, etc.) would be the result of semi-neutral processes, not adaptive evolution.

Richard Meisel
The Pennsylvania State University
University Park, PA
meisel@psu.edu

As an assistant professor constantly thinking about tenure (thus, thinking about funding), I couldn't agree more with Adam Jaffe's assertion in "Double research funding? Be careful" 1 that the current funding situation is bad, frightening, terrifying, ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 
The Immunology of the Brain

The Immunology of the Brain

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit