In cancer research, scientists primarily use genetic sequencing to collect information from liquid biopsy samples. However, traditional methods only provide information on somatic mutations, which can be challenging to detect in low abundance circulating cell-free DNA. Researchers need multiomic methods that provide complete genetic and epigenetic information from a single low input sample for more comprehensive biomarker discovery.
Download this technical note from biomodal to discover how sequencing the six-base genome and capturing 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) profiles alongside all four canonical bases can help scientists
- Differentiate cancer from non-cancer samples
- Generate new information for novel biomarker discovery in cfDNA samples
- Build more accurate multimodal disease classifiers and detect biological changes in patient samples
