N. Kato, M. Hijikata, Y. Ootsuyama, M. Nakagawa, et al., "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis," Proceedings of the National Academy of Sciences, 87:9524-28, 1990.
Nobuyuki Kato (National Cancer Center Research Institute, Tokyo): "Hepatitis C virus (HCV) is the major etiological agent of posttransfusional non-A, non-B hepatitis (NANBH) throughout the world. NANBH frequently develops into chronic hepatitis and cirrhosis and hepatocellular carcinoma. In 1989, a cDNA clone derived from HCV was obtained by a group at Chiron Corp. in Emeryville, Calif. (Science, 244:359-62, 1989). However, the entire HCV genome of this group was not published until March 1991, in spite of its importance in the field of medical science.
"Our report on the molecular cloning of an entire HCV genome from Japanese patients is the first report concerned with nucleotide sequences of an entire HCV genome. At the same time, ...
