Mutation Station: Transgenomic's WAVE System Eliminates Base-by-Base Search

A minor alteration in a single gene of the human body can be a major contributor to the development of a wide spectrum of diseases ranging from cystic fibrosis to cancer. With the Human Genome Project in full swing, the number of genes available to analyze for these changes is growing daily. The increased demand for genetic testing also requires rapid screening capabilities. Transgenomic Inc. recognized this need and has designed an automated high-throughput system for mutation detection. Trans

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

A minor alteration in a single gene of the human body can be a major contributor to the development of a wide spectrum of diseases ranging from cystic fibrosis to cancer. With the Human Genome Project in full swing, the number of genes available to analyze for these changes is growing daily. The increased demand for genetic testing also requires rapid screening capabilities. Transgenomic Inc. recognized this need and has designed an automated high-throughput system for mutation detection. Transgenomic's WAVE Nucleic Acid Fragment Analysis System eliminates the need to search base by base for a single alteration by detecting mutations in regions of DNA as large as 1.5 kilobases at one time.

Transgenomic's temperature modulated heteroduplex analysis system The WAVE System couples the efficiency of heteroduplex analysis (HA) with the convenience of chromatography in a highly automated system that makes mutation detection faster than blind sequencing or gel-based HA methods. ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Amy Francis

    This person does not yet have a bio.

Published In

Share
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital
Concept illustration of acoustic waves and ripples.

Comparing Analytical Solutions for High-Throughput Drug Discovery

sciex

Products

Atelerix

Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome