Neuroscience/Apoptosis

Edited by Neeraja Sankaran R.R. Ratan, T.H. Murphy, J.M. Baraban, "Oxidative stress induces apoptosis in embryonic cortical neurons," Journal of Neurochemistry, 62:376-9, 1994. (Cited in more than 40 publications through November 1995) Comments by Rajiv Ratan, Johns Hopkins University School of Medicine, Baltimore According to Rajiv Ratan, an assistant professor of neuroscience at Johns Hopkins University School of Medicine, the significance of this paper is that it begins to address the mechan

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Edited by Neeraja Sankaran

R.R. Ratan, T.H. Murphy, J.M. Baraban, "Oxidative stress induces apoptosis in embryonic cortical neurons," Journal of Neurochemistry, 62:376-9, 1994. (Cited in more than 40 publications through November 1995) Comments by Rajiv Ratan, Johns Hopkins University School of Medicine, Baltimore

According to Rajiv Ratan, an assistant professor of neuroscience at Johns Hopkins University School of Medicine, the significance of this paper is that it begins to address the mechanisms underlying the pathogenesis of a large number of neurodegenerative disorders. These conditions include Parkinson's and Alzheimer's diseases, AIDS-related dementia, and familial amyotrophic lateral sclerosis (ALS).

Ratan and Murphy SWITCH: Authors, from left, Rajiv Ratan, Timothy Murphy, and Jay Baraban showed that oxidation can induce apoptosis rather than necrosis.

Until this paper was published, "oxidative stress was believed to induce neuronal degeneration by necrosis alone," Ratan recounts. Using an experimental system devised to induce oxidative stress in cells in culture (T.H. Murphy ...

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