New Spin On Ultracentrifuges

The article on analytical ultracentrifugation (Franklin Hoke, The Scientist, Nov. 9, 1992, page 18) was well-written and informative but had one omission. It did not mention the National Analytical Ultracentrifugation Facility, which is part of the Biotechnology Center at the University of Connecticut. This facility was set up by an initial grant from the National Science Foundation in 1988. The principal investigators are Emory H. Braswell, Todd M. Schuster, and David A. Yphantis. The facility

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In addition to the new Beckman XLA, the facility maintains four model E instruments equipped with advanced electronics and cells developed at the facility, increasing the efficiency of the technique more than 20-fold. Although it has been suggested that we are maintaining the most complete working museum of Model Es in the world, for some studies the Model E has not yet been superseded by the new machine.

Utilizing software and research strategies developed at the facility, we do complete analyses of self-association and hetero- association of molecules, such as DNA oligomer proteins, peptides, and inorganic complexes. We are also studying nonaqueous systems, such as buckyballs in toluene.

After an initial development period, the facility has been involved in 30 research projects with 18 academic and 12 industrial collaborators.

We have worked closely with Beckman Instruments Inc. of Fullerton, Calif., helping them in the development of a data- analysis package, ...

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