p53 and the sea

The 18th Lorne Cancer Conference Erskine on the Beach in Lorne, Australia, closed today, but not before p53 competed with the scenery for scientists' attention. Just as the linkurl:Keystone Symposia;http://www.the-scientist.com/blog/display/23090/ are set up to allow for skiing in the afternoon, Lorne is set up to nice long break in the middle of the day during which delegates play tennis on grass courts, swim at the sweeping beach across the road or just laze on the grass in the sun. Tony Brai

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share
The 18th Lorne Cancer Conference Erskine on the Beach in Lorne, Australia, closed today, but not before p53 competed with the scenery for scientists' attention. Just as the linkurl:Keystone Symposia;http://www.the-scientist.com/blog/display/23090/ are set up to allow for skiing in the afternoon, Lorne is set up to nice long break in the middle of the day during which delegates play tennis on grass courts, swim at the sweeping beach across the road or just laze on the grass in the sun. Tony Braithwaite, from the University of Otago, in New Zealand, reported on efforts to figure out the role of p53's N-terminal polyproline domain in apoptosis. Looking at mice with a homozygous deletion in the proline rich region showed that they showed no evidence of spontaneous tumor formation. 'Either apoptosis is not the critical determiner of tumor suppression by p53,' he said, 'or the polyproline domain is not essential for apoptosis.' The schedule included an international cast of speakers on cancer genetics and epigenetics, including Carlo M. Croce, chairman of the College of Medicine and Public Health at Ohio State University, who described some of the work his group has done in elucidating the relationship between specific micro RNA expression signatures and prognosis in chronic lymphocytic leukemia. Gerard Evan from the UCSF Comprehensive Cancer Center described his very useful knock-in mouse model in which the regular p53 gene is replaced by one that encodes an ectopically and reversibly switchable p53ER/TAM protein. Simply by administering a ligand, the mice can be switched between p53 null and wild type, allowing Evan's group to examine when, where and how p53 functions in vivo to suppress neoplasia.
Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Stephen Pincock

    This person does not yet have a bio.
Share
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital
Concept illustration of acoustic waves and ripples.

Comparing Analytical Solutions for High-Throughput Drug Discovery

sciex

Products

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome

Magid Haddouchi, PhD, CCO

Cytosurge Appoints Magid Haddouchi as Chief Commercial Officer