C. Heurteaux et al., "Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype," Nat Neurosci, 9:1134-41, September 2006.
A deletion in the KCNK2 gene encoding the two-pore domain potassium channel Trek-1 results in antidepressant-like behaviors. Intriguingly, a previous report showed that this channel is inhibited by antidepressants that target neurotransmitter reuptake inhibitors at near-therapeutic concentrations (Kennard et al., Br J Pharmacol, 144:821-9, 2005 | [PubMed]). Therefore, the antidepressant activity of SSRIs may include a Trek-1 component.
Marcos Milla
Roche, Palo Alto, Calif.
F.S. Alkuraya et al., "SUMO1 haploinsufficiency leads to cleft lip and palate," Science, 313:1751, Sept. 22, 2006.
Genomic analysis of a 5-year-old girl born with a unilateral cleft lip and palate revealed disruption of the SUMO1 gene. The protein that must be modified by SUMO1 to prevent abnormal palate development was not identified in the study; however, a possible candidate is Eya1.
Richard L. StevensBrigham and ...
