J.C. Hermann et al., "Structure-based activity prediction for an enzyme of unknown function," Nature, 448:775-9, Aug. 16, 2007.
The X-ray crystallographic structure of the gene product Tm0936 from the amidohydrolase superfamily, deposited by a structural genomics consortium, was used to dock, score, and sort a library of 22,500 high-energy intermediates as ligands, leading to the successful prediction that the enzyme acts as an S-adenosylhomocysteine deaminase.
--Karen Allen
Boston University School of Medicine, United States
C.V. Carman et al., "Transcellular diapedesis is initiated by invasive podosomes," Immunity, 26:784-97, June 2007.
The authors ... show that leukocytes use a protrusive type of podosome to probe the surface of the underlying endothelial cell, and eventually to push organelles out of the way as the leukocytes migrate through.
--Carol Otey
University of North Carolina, Chapel Hill, United States
S.M. Kaiser et al., "Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein," Science, 316:1756-8, June ...
