Edited by Karen Young Kreeger
M.P. Gray-Keller, P.B. Detwiler, "The calcium feedback signal in the phototransduction cascade of vertebrate rods," Neuron, 13:849-61, 1994. (Cited in more than 30 publications through June 1996)
Comments by Mark Gray-Keller, University of Washington, Seattle
The biochemical reactions governing vision are some of the most complex and sensitively regulated processes in the human body. In vertebrate retinal photoreceptors-called the rods and cones-calcium ions play a key role in the process that converts light into an electrical signal. This transformation of a physical stimulus into a biologically useful signal is the first step in vision.
EYE-OPENER: University of Washington's Mark Gray-Keller and colleagues studied the role of calcium feedback signals in science. "I think this paper has received a lot of attention because we describe for the first time the magnitude and time course of the change in intracellular calcium that accompanies the light response in ...
