Probing Questions

Nucleic Acid Labeling Kits Nucleic Acid Labeling Kits (continued) Nucleic Acid Labeling Kits (continued) Genisphere's 3DNA™ Expression Array Detection Kit reagents The ability to label nucleic acids with a variety of tagged molecules has led to astonishing advances in molecular biology. Labeled DNA, RNA, and oligonucleotide probes have made possible techniques like the historic Southern blot, the northern blot, and related dot/slot-blotting procedures, in addition to in situ hybridizat

Written byMichael Brush
| 7 min read

Register for free to listen to this article
Listen with Speechify
0:00
7:00
Share

Nucleic Acid Labeling Kits

Nucleic Acid Labeling Kits (continued)

Nucleic Acid Labeling Kits (continued)


Genisphere's 3DNA™ Expression Array Detection Kit reagents
The ability to label nucleic acids with a variety of tagged molecules has led to astonishing advances in molecular biology. Labeled DNA, RNA, and oligonucleotide probes have made possible techniques like the historic Southern blot, the northern blot, and related dot/slot-blotting procedures, in addition to in situ hybridization studies and colony and plaque lifts. Recently, labeled cDNA probes have become an integral part of the gene expression analysis advances empowered by gene arrays. Beginning with the enzymatic incorporation of radioactivity and eventually employing nonisotopic alternatives, labeling methods and kits have evolved into a host of products and creative technologies that offer some powerful tools to the life scientist.

To label probes by nick translation, DNase I is used to create free 3' hydroxyl ends (nicks) within an unlabeled ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo