M. Lagouge et al., "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α," Cell, 127:1109-22, 2006. (Cited in 139 papers)
In 2006, Johan Auwerx of the Institute of Genetics and Molecular and Cellular Biology in France and colleagues treated mice with resveratrol (RSV), a natural plant compound known to extend lifespan in yeast, in order to test its impact on metabolism. RSV-fed mice, even on a high-fat diet, had increased muscle strength and longer running times than control mice. Not only were they resistant to diet-induced obesity, the RSV mice had lower body weights than normal-fed mice.
While RSV had been known to activate the metabolic regulator SIRT1 in vitro, the Hot Paper proved it had similar effects in mice. Additionally, it showed that RSV also activates PGC-1α, a transcription coactivator known to interact with SIRT1 that stimulates mitochondrial biogenesis. PGC-1α "is important to increase ...
