"Save the mice" may sound like an animal rights slogan, but it is smart science to researchers in the Comparative Mouse Genomics Center at the University of Washington in Seattle. A major drawback of working with laboratory mice is having to kill the animals to measure endpoints such as tumor development and bone loss. Director Warren Ladiges, a veterinarian, and his colleagues are trying to save mice--and the cost of replacing them--by developing noninvasive techniques for whole-body imaging.

Photo Courtesy of Robert Miyaoka
 VET PET POWER: A micro-crystal element (MICE) detector module for the PET system. This array, comprised of 22 x 22 crystals, each 0.8 mm x 0.8 mm, is inserted into a grid made of a highly reflective polymer film.

Radiochemist Kenneth Krohn created a mouse-sized positron emission tomography (PET) scanner. The project also uses equipment designed for humans: a Lorad MII X-ray mammography unit and a Norland...

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