Serotonin, Repurposed

Immune Control CEO Stephen Roth is banking on a controversial hypothesis and is fashioning ways to block a neurotransmitter to fight autoimmune disease.

Written byAndrea Gawrylewski
| 6 min read

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

In 2002 Stephen Roth, who was about to retire as CEO of biotech Neose Technologies, sat down with two scientists from Drexel University to judge whether a new scientific concept made any sense.

The scientists began their presentation, explaining that they believed that serotonin - the much-studied neurotransmitter associated with depression - was a key growth factor for lymphocytes. "My first reaction was: 'Bullshit'," remembers Roth.

But after a lengthy discussion, and reading a pile of literature showing that serotonin was widely distributed in immune tissues,1 and upregulates B and T lymphocytes,2 Roth came around. So much so, he became the new CEO at a biotech devoted to developing the technology: Immune Control. As CEO, Roth's business now is to convince investors that the serotonin idea, no matter how off-the-wall it may seem, is indeed sound. Using their funds, Roth runs a virtual company with only four full-time employees that ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo