The paper
N. Frankel et al., “Phenotypic robustness conferred by apparently redundant transcriptional enhancers,” Nature, 466:490-93, 2010. Free F1000 Evaluation
The finding
Are redundant copies of noncoding DNA sequences due to poor genomic housekeeping, or do they function to improve the organism’s chances of survival? David Stern at Princeton University and colleagues attacked this question by looking at duplicate or “shadow” versions of enhancers, noncoding regions that regulate and promote gene expression. When he knocked out duplicate enhancers for the fruit fly gene shavenbaby, which codes for larval hair growth , he found that the flies were unable to produce hairs in nonoptimal environments, supporting the hypothesis that redundant genetic elements make an organism more robust.
The test
When Stern deleted the duplicate enhancers in drosophila embryos, the larvae grew with a normal number of hairs, suggesting, on first blush, that the duplicates were unnecessary.Stern wondered, however, whether the duplicates ...
