Edited by: Paul Smaglik
Z. Liu, H. Hsu, D.V. Goeddel, M. Karin, "Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis, while NF-[kappa]B activation prevents cell death," Cell, 87:565-76, 1996. (Cited more than 70 times through November 1997)
Comments by Michael Karin, Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California, San Diego
SIGNAL DISSECTION: Michael Karin and colleagues picked apart the steps in TNF receptor 1 signaling to reveal three separate but interrelated pathways. Unlike more specialized cytokines, tumor necrosis factor (TNF) initiates a variety of biological responses. Some-like cell proliferation and apoptosis-seem in opposition to each other. But picking apart the steps in the signaling pathway reveals how one receptor can control both. Understanding these steps is especially important because most cells have some sort of a TNF receptor. "We have dissected the components," says Michael Karin, a professor ...
