Signal Transduction

Edited by: Thomas W. Durson Z. Songyang, S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X.R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R.A. Feldman, L.C. Cantley, "Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav," Molecular and Cellular Biology, 14:2777-85, 1994. (Cited in nearly 150 publications through April 1996) 'WIDE RANGE': Lewis Cantley developed optimum motifs for SH2 domains. Comments

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Edited by: Thomas W. Durson
Z. Songyang, S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X.R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R.A. Feldman, L.C. Cantley, "Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav," Molecular and Cellular Biology, 14:2777-85, 1994. (Cited in nearly 150 publications through April 1996)

'WIDE RANGE': Lewis Cantley developed optimum motifs for SH2 domains.

Comments by Lewis C. Cantley, Harvard Medical School and Beth Israel Hospital, Boston

The Src homology region 2 (SH2) domain of enzymes controls a series of protein-protein interactions in which components of the signal transduction process activate one another (Hot Papers, The Scientist, Dec. 9, 1991, page 16). In this paper, researchers detailed how they developed optimum motifs for several SH2 domains.

"We were able to establish some general principles for what type of ...

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