SIV attacks memory cells

Credit: PROFESSORS PIETRO M. MOTTA © TOMONORI NAGURO / PHOTO RESEARCHERS" /> Credit: PROFESSORS PIETRO M. MOTTA © TOMONORI NAGURO / PHOTO RESEARCHERS The paper: J.J. Mattapallil et al., "Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection," Nature, 434:1093-7, 2005. (Cited in 98 papers) The finding: Simian immunodeficiency virus (SIV) and HIV are known to reduce CD4+ T cells dramati

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

The paper:

J.J. Mattapallil et al., "Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection," Nature, 434:1093-7, 2005. (Cited in 98 papers)

The finding:

Simian immunodeficiency virus (SIV) and HIV are known to reduce CD4+ T cells dramatically. Research by Mario Roederer at the National Institute of Health and his colleagues showed that this happens during acute infection, suggesting that this is an important time to reduce viral load therapeutically.

The follow-up:

CD4+ T cells in SIV-infected infant macaques have the same rate of depletion, according to in press work by Ronald Veazey at Tulane University. What's surprising, he says, is the substantial amount of CD4+ T cells in uninfected infants, perhaps suggesting that "the immune system is cranked up very early after birth."

The application:

Roederer's team reported in 2006 that vaccination reduces CD4+ T cell depletion during acute SIV infection in ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Cathy Tran

    This person does not yet have a bio.

Published In

Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio