Small nucleolar RNAs (snoRNAs) have never before been implicated in alternative splicing. Stefan Stamm and Shivendra Kishore, of the Friedrich-Alexander University Institute for Biochemistry, suggest that HBII-52, a non-coding RNA located on chromosome 15 regulates alternative splicing of the serotonin receptor 2C located on the X chromosome.
Tom Blumenthal, chair of biochemistry and molecular genetics at the University of Colorado Health Sciences Center, says, "This one just struck me as really novel."
"This is in fact a very interesting case of alternative splicing because it means the difference between making a functional and a non-functional serotonin receptor. So, it is by its nature a very interesting case of alternative splicing and it turns out to be regulated by what appears to me to be an entirely ...
