Stem cell study trouble

linkurl:Ethical lapses;http://www.the-scientist.com/article/display/54226/ and procedural breakdowns plagued an Austrian clinical trial of a linkurl:stem cell therapy;http://www.the-scientist.com/news/display/53610/ that used patients' own cells to treat urinary incontinence, according to a report recently released by the country's Agency for Health and Food Safety (AGES). The AGES report says that urologists involved in the study engaged in a series of questionable activities: They designed th

Written byBob Grant
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share
linkurl:Ethical lapses;http://www.the-scientist.com/article/display/54226/ and procedural breakdowns plagued an Austrian clinical trial of a linkurl:stem cell therapy;http://www.the-scientist.com/news/display/53610/ that used patients' own cells to treat urinary incontinence, according to a report recently released by the country's Agency for Health and Food Safety (AGES). The AGES report says that urologists involved in the study engaged in a series of questionable activities: They designed the trial poorly, inadequately randomized patients, conducted the trial without the appropriate ethics approval, and failed to properly inform trial participants about the nature of the study. The study was published last year in linkurl:__The Lancet__.;http://www.thelancet.com/journals/lancet/article/PIIS0140673607610149/abstract linkurl:Hannes Strasser,;http://www.uro-innsbruck.at/inkontinenz/englisch/website_en/mitarbeiter.htm a Medical University of Innsbruck, Austria, urologist and the study's lead author, is mentioned throughout the AGES report. According to linkurl:__Nature__,;http://www.nature.com/news/2008/080814/full/454922a.html Medical University of Innsbruck administrators have barred Strasser from seeing patients in the university's hospital. Strasser has denied any wrongdoing in a letter to the university. The stem cell treatment involved harvesting muscle cells from 42 female patients' arms, using those samples to develop autologous linkurl:myoblasts;http://www.the-scientist.com/article/display/24104/ and linkurl:fibroblasts,;http://www.the-scientist.com/blog/display/54308/ then implanting the stem cells into patients' urinary sphincters. Several of the patients treated by Strasser and his colleagues, both as part of the trial and outside the study, have reported severe side effects, including sealing of the urinary sphincter and ruptured linkurl:bladders,;http://www.the-scientist.com/article/display/53878/ according to __Nature__. Suspicion of the study was initially raised by the university's rector, linkurl:Clemen Sorg,;http://www.i-med.ac.at/mypoint/news/2007111301.xml who told university researchers of his concerns in November of last year. The AGES report absolves Strasser's co-author and head of the urology department, linkurl:Georg Bartsch,;http://www.uro-innsbruck.at/vorwort/englisch/index_en.htm from any blame in the case. Bartsch told __Nature__ that he was included as an author on the paper "in honor of my seniority." However, Bartsch headed a university committee that initiated the installment of guidelines for "good scientific practice" by faculty, and signed off on many of the documents relating to the controversial stem cell therapy. University officials have asked that Strasser retract __The Lancet__ paper and another related linkurl:paper;http://www.springerlink.com/content/n2156mk37663k445/ by August 18. The Austrian Academy of Sciences has suspended its investigation of the alleged misconduct while university officials decide on further disciplinary actions against Strasser and Bartsch.
Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

    View Full Profile
Share
Image of a man in a laboratory looking frustrated with his failed experiment.
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Graphic of amino acid chains folded into proteins

Expi293™ PRO Expression System: Higher Yields Across a Wider Variety of Proteins

Thermo Fisher Logo