Stem Cells and Gene Therapy

Stem Cells and Gene Therapy Researchers take a second look at using stem cells to treat HIV By Bob Grant Related Articles 5 HIV Treatment Strategies A piggyback attack: Using the common cold to deliver an HIV vaccine The best offense? CCR5 inhibitors, with one now on the market, suggest it may be a good defense Solving the viral spike: Can structural biology find a chink in HIV's armor? Reconstructing early HIV: The search for immunogens d

Bob Grant

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By Bob Grant

5 HIV Treatment Strategies

A piggyback attack: Using the common cold to deliver an HIV vaccine

The best offense? CCR5 inhibitors, with one now on the market, suggest it may be a good defense

Solving the viral spike: Can structural biology find a chink in HIV's armor?

Reconstructing early HIV: The search for immunogens delves into the virus' past

Profile: A Receptive Leader: Panacos' Graham Allaway

PODCAST: Andrea Gawrylewski interviews NIAID director Anthony Fauci, who gives his take on HIV research priorities.

Stem cells enjoyed a short run as potential gene therapy vehicles in the 1990s. Most approaches suffered, however, from low expression levels and low transduction efficiencies in target cells. Though researchers had developed a rich array of anti-HIV genes, including antisense and virion fusion inhibitors, RNA decoys, and short hairpin RNAs, their in vitro effectiveness did not translate into significant therapeutic effects in patients.

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