Courtesy of Joseph McPartlin

1. In the age of nanofluidics, the 24-hour urine collection may seem a curiosity, though much depends in metabolic studies on the accuracy of collecting these specimens. In an account worthy of Italian satirist Dario Fo, the authors Turner and Merlis1 recount the sources of errors during collections. They also compare working with human subjects to an enormous game of chess, and quote George Eliot's Felix Holt:

Fancy what a game of chess would be if all the chess men had passions and intellects, more or less small and cunning; if you were not only uncertain about your adversary's men, but a little uncertain also about your own .... You might be the longest headed of deductive reasoners, and yet you might be beaten by your own pawns .... Yet this imaginary chess is easy, compared with a game a man has to play...

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