Uncovering a Genome's Regulatory Circuitry

For this article, Jennifer Fisher Wilson interviewed Richard A. Young, professor of biology at the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, in Cambridge, Mass. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. F.C. Holstege, E.G. Jennings, J.J. Wyrick, T.I. Lee, C.J. Hengartner, M.R. Green, T.R. Golub, E.S. Lander, and R.A. Young RA. "Dissecting the regulatory circuitry of a eukaryotic genome," Cell, 95:717-28, Nov. 25, 1998. (Cited in about 185 papers since publication) Over the past decade, scientists have learned much about the genome's transcription apparatus and about its regulation, but little about genome-wide expression circuitry. Uncovering this circuitry is fundamental to understanding living processes. Cells must adjust genome expression to accommodate changes in their environment and in their programs of growth control and development, and ...