Validating the Interactome

MOLECULAR CARTOGRAPHY:Recognizing that much of the cell's work is done not by individual proteins but by large macromolecular complexes, researchers increasingly are trying to map protein-protein interactions throughout the cell. This map of the C. elegans interaction network, or "interactome," links 2,898 proteins (nodes) by 5,460 interactions (edges). (reprinted with permission, Science, 303:540–3, 2004.)If you want a sense of one of the hottest trends in biology today, open the hood of

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Recognizing that much of the cell's work is done not by individual proteins but by large macromolecular complexes, researchers increasingly are trying to map protein-protein interactions throughout the cell. This map of the C. elegans interaction network, or "interactome," links 2,898 proteins (nodes) by 5,460 interactions (edges). (reprinted with permission, Science, 303:540–3, 2004.)

If you want a sense of one of the hottest trends in biology today, open the hood of your car. At first, the jumble of boxes, wires, circuitry, and hoses that meets your eyes more likely will confuse than inform. Careful examination, however, exposes an intricate order, in which modular processes interact with each other to build ever-larger systems, culminating in a working automobile.

A cell presents an equally confusing array of parts. But like the car, the cell can be analyzed as a series of interacting systems working together to build a whole greater than its ...

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