Courtesy of Greg Suh, University of California Los Angeles, Andrew Moore, InfrancoMoore Group
This developing eye from a chimeric Drosophila has wild-type tissue at the top and csn5 mutant tissue at the bottom causing disorganization. Overlaid is a schematic showing the predicted metalloprotease site of CSN5 cleaving an isopeptide bond.
It doesn't take a green thumb to predict what happens to plants left in the dark: They wither. But in the late 1980s and early 1990s, researchers, including people in Xing-Wang Deng's Yale University lab, stumbled upon a group of intriguing
In 1994, Deng's group identified COP9, one of the genes responsible for this impressive feat.1 After doing some ...