1991 Nobel Prize Winners Sparked Fundamental Advances

The 1991 Nobel Prize winners in science were announced last month, and for the first time in 43 years, none of the laureates is from the United States. Yet their work--in nuclear magnetic resonance spectroscopy, phase transitions in materials science, and patch-clamp methodologies--collectively has influenced research in the U.S. and throughout the world. As is typical of Nobel Prize winners, their pioneering advances have changed the way science is done across the spectrum of scientific discip

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Chemistry

The Royal Swedish Academy of Sciences awarded the Nobel Prize in chemistry to Swiss chemist Richard R. Ernst, of the Eidgen”ssische Technische Hochschule (ETH) in Zürich, Switzerland. Ernst's contributions to the development of nuclear magnetic resonance (NMR) spectroscopy have made the technique nearly indispensable in many of today's scientific laboratories studying a wide range of phenomena, such as the three-dimensional structure of proteins, the chemical interactions of molecules in solution, and the effects of drugs on metabolic processes.

Although Ernst has been active in the field of NMR spectroscopy for some 30 years, he was recognized by the Nobel committee primarily for two fundamental advances, Fourier-transform NMR (FT-NMR) and two-dimensional NMR (2D-NMR).

NMR was developed in the 1940s by two independent groups, Felix Bloch's at Stanford University and Edward Purcell's at Harvard University; both men shared the Nobel Prize in physics in 1952. Although NMR's analytical potential was recognized ...

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