Courtesy of Bio-Rad

Bio-Rad's Mini-PROTEAN 3 system

Graphic: Leza Berardone
The inevitable inventory of genes that will be produced by the Human Genome Project heralds the start of a new era: the Age of Proteomics. Although DNA is the blueprint for life, it is the set of proteins that are actually transcribed and translated that determine the function of a particular cell. Proteomics is the study of the complete protein complement of the cell, tissue, or organism. Central to this burgeoning field is two-dimensional (2-D) gel electrophoresis.1,2

Several thousand different proteins are expressed at any one time in a particular sample tissue or organism; 2-D gel electrophoresis makes it possible to resolve these proteins. Scientists may compare samples from normal and diseased tissues, or from tissue samples harvested over the course of development, to identify those proteins whose expression levels change. With the 2-D...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?