A Revolutionary Approach to Biomarker Discovery

A Revolutionary Approach to Biomarker Discovery Immunoassays coupled with mass spectrometrycould reveal new dimensions in the blood  By Emanuel F. Petricoin and Lance A. Liotta ARTICLE EXTRAS Proteomics: Promise and ProblemsSuch early disease detection doesn't always mean longer life, write JENNIFER MILLER and BARNETT KRAMER. INFOGRAPHIC: The Peptidome Hypothesis:What does a disease signature look like in the blood? Serum Proteomics ScrutinizedSELDI-TOF st

| 12 min read

Register for free to listen to this article
Listen with Speechify
0:00
12:00
Share

Immunoassays coupled with mass spectrometry
could reveal new dimensions in the blood

By Emanuel F. Petricoin and Lance A. Liotta

Based on evidence that indicates an alarming decline in the number of FDA-approved diagnostic tests for disease detection over the past 15 years,1 it might seem that the biomarker pipeline is running dry. But before succumbing to this view, it is of utmost importance we take a closer look at the circulatory proteome.

While questions remain as to whether detecting diseases at their earliest stages actually improves health (see "Proteomics: Promise and Problems"), most agree that screening approaches have led to dramatic changes in the outcome of some cancers such as cervical cancer.2 We see a future that expands on this promise: one in which diseases can be diagnosed in their earliest stages in hopes of effective intervention, but also where new classes of sensitive imaging technology (e.g., Spiral CT) are ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Emanuel F. Petricoin

    This person does not yet have a bio.
  • Lance A. Liotta

    This person does not yet have a bio.

Published In

Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio