Angiogenesis--Promoting and Blocking--Comes Into Focus

Blocking and promoting angiogenesis--the development of blood vessels--is a rapidly advancing strategy that offers opportunities to treat a spectrum of diseases. The strategy views blood vessel growth and inhibition as the linchpin in certain diseases. Stopping the growth of blood vessels from tumors, for instance, means there is no highway for metastasis, the spread of cancer from its primary site. On the other hand, increasing blood vessel growth can help ischemic, or blood-starved, hearts.

Written byHarvey Black
| 8 min read

Register for free to listen to this article
Listen with Speechify
0:00
8:00
Share

The strategy views blood vessel growth and inhibition as the linchpin in certain diseases. Stopping the growth of blood vessels from tumors, for instance, means there is no highway for metastasis, the spread of cancer from its primary site. On the other hand, increasing blood vessel growth can help ischemic, or blood-starved, hearts.

"Almost everyone you talk to has one particular goal: The cardiologists want to make new blood vessels, the allergists want to stop inflammation, the cancer specialists want to stop cancers, the dermatologists want to increase blood flow to get better skin tone and to decrease it in psoriasis," observes Robert Auerbach, a professor of biology at the University of Wisconsin, Madison.

In adults, the network of blood vessels is stable. Normal angiogenesis occurs during the menstrual cycle and when the body needs to repair wounds.

BURGEONING FIELD: William Huse, chief scientific officer of IXSYS Inc., describes the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Image of a man in a laboratory looking frustrated with his failed experiment.
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies