Courtesy of David S. GoodsellRibosomal proteins, classically thought to function only as translational machinery, now appear to play a role in the HDM2-p53 pathway. Recent work by scientists at the University of Texas MD Anderson Cancer Center in Houston shows that during cell-growth inhibition, ribosomal protein L11 translocates from the nucleolus to the nucleoplasm where it binds HDM2 (human double minute 2), disrupting HDM2's contact with tumor suppressor p53.1 Without HDM2-mediated p53 ubiqu

© 2004 Nature Publishing GroupConstantly on the run, membrane-bounded organelles (MBOs) in neurons deliver proteins from cell bodies to axons. A recent study by Scott Brady and colleagues at the University of Illinois suggests that disruption of this anterograde fast axonal transport (FAT) may contribute to Alzheimer disease pathogenesis via a novel pathway locally regulating glycogen synthase kinase-3 (GSK3) activity.1According to this study, cyclin-dependent kinase 5-inhibition allows pro