The recent article "Assessing Amyloid β"1 discusses recent evidence for a physiological role for amyloid-β. Surprisingly, given such a role, the potential danger of removing this physiological protein is scant. However, this is exactly what the next generation "treatment" strategies are targeting. The termination of the initial clinical trial utilizing such a strategy due to side effects of brain inflammation may, however, be a direct consequence of removing physiologically useful amyl

Many view the incessant reliance on Medline and other virtual databases in scientific study as a less scholarly approach toward science. Libraries have been transformed into repositories of digital data rather than the printed word, ready for keystroke experiments. Manuscripts published prior to 1966, the limit of the Medline database, are "virtually" (pun intended) ignored. In many cases, research performed by keywords without cogent scientific rationale leads to tenuous threads holding a manus