Articles by Rabiya Tuma

Courtesy of SR Eng  BABY STAINS: The head of a transgenic murine embryo in which a marker enzyme has been specifically expressed in the sensory neurons of the trigeminal and dorsal root ganglia. The marker allows staining of the projections of these neurons into, among other areas, the hindbrain and spinal cord. (S.R. Eng et al., "Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice," J Neurosci, 21:541-9, 2001.) Somewhere in the 200 million bases of the human ge

Courtesy of Charles River Laboratories Compared to the treatment for other malignancies, brain cancer therapies exist in the dark ages, with prognoses and mortality rates similar to those from 30 years ago. A new generation of murine models, however, could change that situation in relatively rapid order, experts predict. "To put it into perspective how ridiculously bad the [current] situation is, there have been over 100 clinical trials over the past two decades that have translated into appr

The reports of two research groups interested in retrograde signaling caught the attention of investigators at the recent Society for Neuroscience (SFN)meeting; the teams used similar methods but arrived at two distinct conclusions. One team says that there is only one way to send nerve growth factor (NGF) signals from the axon to the cell body. The other group thinks that this retrograde signaling occurs in another way. Previously, scientists thought that when NGF bound to TrkA receptors at