Edited by: Thomas W. Durson
M. Søgaard, K. Tani, R.R. Ye, S. Geromanos, P. Tempst, T. Kirchhausen, J.E. Rothman, T. Söllner, "A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles," Cell, 78:937-48, 1994. (Cited in more than 60 publications through April 1996)
Comments by Thomas Söllner, Memorial Sloan-Kettering Cancer Center, New York
In 1993, James E. Rothman, the program chairman in cellular biochemistry and biophysics at Memorial Sloan-Kettering Cancer Center in New York, and his research team delineated the proteins involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane, a process essential for neurotransmission (T. Söllner et al., Cell, 75:409-18, 1993; Hot Papers, The Scientist, Sept. 4, 1995, page 15). Those findings led them to hypothesize that a specific pair of soluble NSF-attached protein (SNAP) receptors-so-called SNAREs-were responsible for targeting vesicles outside the neuronal synapse.
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